This application note presents a standardized method for measuring in situ biofilm metabolism using isothermal microcalorimetry combined with the BioSurface Technologies MicroWell™ system.

For the cosmetics industry, balancing safety, quality, and natural formulation is a constant challenge. In collaboration with Bunnyroo Inc., the application note demonstrates how biocalorimetry enables rapid and sensitive detection of microbial contamination in skincare products such as face serum and collagen cream.

Chronic wounds are driven by resilient biofilms that standard lab models often fail to capture, risking overestimation of antibiotic efficacy. Using chronic wound medium with Symcel’s isothermal microcalorimetry, this application note reveals hidden drug tolerance and showcases how the calScreener offers a powerful tool for developing effective therapies.

Biocalorimetry enables rapid and highly sensitive microbial detection in consumer goods, overcoming the long delays and limitations of traditional culture-based sterility tests. By measuring microbial metabolic heat in real time, the calScreener® can confirm contamination within hours, even in complex formulations such as hand wash, shower cream, and toothpaste. This approach reduces production risks, improves quality control efficiency, and supports faster, more reliable release of safe consumer products.