CALOTRACE
EXPANDING DETECTION OF LIFE
The caloTrace® is Symcel’s most flexible biocalorimetry platform, designed to turn real-time metabolic monitoring into a powerful solution for microbial QC testing, cell research, and product development across a wide range of applications. It combines ease of use with flexible sample volumes and exceptional measurement sensitivity. Samples can be incubated at temperatures between 20 °C and 40 °C across 30 independently loaded measurement channels.
Continuous monitoring provides immediate notification of microbial presence, often within only a few hours, combined with automatic pass/fail results at the end of the test.
calScreener
ADVANCING DETECTION OF LIFE
All living organisms are metabolically active, and the calScreener® detects cells and microbes through their heat release. This enables high-precision phenotypic detection with faster time to results, higher throughput and greater insight than traditional methods. Measurements are label-free and enable non-destructive in situ testing of a wide range of materials with minimal sample preparation.
The calScreener+ is the second-generation calScreener version offering testing in temperature range from 20 to 40°C with superior signal stability, making it ideal for applications that require the highest sensitivity and flexibility. Whether you are testing for microbial contamination, studying biofilm behavior, evaluating antimicrobial properties, exploring microbial interactions, or performing advanced cell metabolic monitoring, calScreener accelerates time to results, simplifies workflows, and provides insights beyond the reach of standard growth assays.
calScreener+ Sterility
GROWTH-BASED STERILITY TESTING OF ADVANCED THERAPIES AND PHARMACEUTICALS IN UNDER 3 DAYS
Based on highly sensitive isothermal microcalorimetry, the calScreener+ Sterility System combines speed and reliability for sterility testing of cell and gene therapies, biologics, and other ATMPs. It combines alignment with compendial sterility testing methods through dual-temperature testing in standard TSB and FTM media with direct inoculation workflow and accelerated non-destructive growth-based detection of viable microorganisms. The system is inherently flexible in sample handling and can analyze complex cell-based products without filtration or other preparation steps.
Continuous monitoring provides immediate alerts of microbial contamination, often within only a few hours. Using metabolic heat flow-based detection, the system can detect slow-growing organisms such as C. acnes in less than 60 hours at 5 CFU, enabling sterility testing timelines to be reduced from the traditional 14-day compendial method to under 3 days.
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CALVIEW
CONTROL, ANALYZE, REPORT
The calView® software is Symcel's dedicated platform for control, data acquisition, analysis, and reporting for the calScreener® and caloTrace® systems. Designed for both quality control and research applications, it provides tools for data interpretation and visualization of continuous thermogram curves for each measurement.
The software includes a sterility testing module for dual-temperature measurements aligned with pharmacopeial testing methods. It provides clear automated positive/negative result interpretation and consolidated reporting. An optional 21 CFR Part 11 module supports compliance through user authentication, audit trails, electronic signatures, and data integrity features.
