What do you get?
The calScreener™, configured for measurement at 37 °C, consists of a thermostat, a calorimeter unit, and a computer with the calView™ software for instrument control and data acquisition. The calScreener™ Installation Kit and the calScreener™ Start-up Kit contain everything you need to get started.
Samples can be loaded into either re-usable vials in titanium (< 600 µL) with single-use sterile plastic inserts (< 400 µL) for easy sample retrieval, cleaning and maintenance. You can also use single-use sterilized glass vials (< 500 µL). Each vial type requires its own specific sample handling plates and setup, which should be specified upon order.
You can measure at other temperatures between 32°C and 42°C by adding one or several temperature adapters for a specific temperature.
calPlate™ - the sample plate
The calPlate™ is a 48-well sample plate specifically optimized for loading calVials into the calScreener with high precision, ensuring highly sensitive biocalorimetric measurements. The 48-well format lets you quickly and efficiently load up to 32 samples simultaneously, while the remaining 2×8 positions serve as calorimetric references, enhancing both sensitivity and overall performance.
calPlate™ for Titanium Vials
The calPlate™ for titanium vials is designed for the precise loading of calVials made from titanium into the calScreener, ensuring optimal performance during high-precision calorimetric testing.
calPlate™ for Glass Vials
This version of the calPlate™ is designed for loading disposable glass vials into the calScreener, offering a seamless and optimized fit for precise and consistent biocalorimetric experiments.
calVial™ - glass or titanium vials
calVials™ in Titanium
Calorimetric experiments can be run directly in the titanium calVial™ or using the optional single-use plastic insert. The plastic inserts are optical grade and can be either non-activated or activated plastic inserts. The single-use plastic inserts facilitates sample retrieval, cleaning, and maintenance of the vials.
All inserts are delivered sterile for easy handling and can be used directly. Inserts are available in two versions:
calVials™ in glass
The capped, single-use sterile glass vial has a sample volume capacity of less than 500 µL. Each vial comes closed with aluminum caps with a rubber septum. The closed vials are not fully sealed, allowing for easy injection of media and samples through the septum without the risk of overpressure. Once the sample has been injected, the vial can be fully sealed using an automatic electric crimping tool.
Each package contains four heat-sterilized vials, which are packed in either a single-layered or triple-layered bags.
calVial™ Inserts (plate) – a 48-well plate with 48 inserts. For easy set-up and pipetting. The inserts can easily be transferred to the calorimeter vials after preparation
calVial™ Inserts (pouch) – A box with 24 pouches of 16 (+2) individual inserts.
The inserts are used only for the titanium vials. They are conveniently packaged in separate pouches to minimize plastic waste and reduce overall costs. This provides enough inserts to run twelve full experiments when using the solid references. This is the recommended option if solid references are used and/or in case not all calorimeter positions are used.
Calorimetric references
The calScreener™ is a differential microcalorimeter where sample heat flow is measured against an inert reference, also referred to as a calorimetric reference. The reference increases the quality of the signal and sensitivity of the calorimeter by cancelling out any disturbances and increases the signal-to-noise ratio. The calorimeter reference should be completely inert with similar calorimetric properties as the sample. A sample vial can be filled with media or water that is prepared for each experiment or a preprepared inert reference or sample vial can be used.
Solid references for use with the calVials™ in Titanium
To mimimize the risk of leakage from and contamination in the refence vials there is an option to use solid references. The use of solid references will also save preparation time as the reference vials, once prepared can be used unlimited times as long as the sample volume is the same.
The solid references comes in sets matching sample volumes of 100, 150, 200 and 400 µL. The references can be combined for other volumes, with the kit of 100, 150 and 200 µL references.
Inert reference sample for use with the calVials™ in glass
To ensure accurate measurements, each sample is paired with a calorimetric reference. The calorimeter reference should be completely inert with similar calorimetric properties as the sample. The system includes a full set (48) of these inert reference samples that also can be used as dummies for any unused sample positions.
calView™
The state-of-the-art calView™ 2.0 software is designed to give you complete control over your calorimetric experiments, providing built-in analysis and reporting capabilities. calView™ provides both instrument control and data acquisition, allowing you to manage your experimental setup. You can input detailed sample information and display real-time data in a variety of formats to suit your analysis needs.
This powerful software offers a comprehensive view, enabling you to monitor all test graphs simultaneously or zoom in for a close-up examination of individual test results. Once the experiment is complete, you can generate detailed reports that include data from multiple experiments, or export the results for further analysis.
In addition, calView™ can be integrated with a 21 CFR Part 11 compliant software module, providing robust support for electronic records and signatures. This module enables users to enforce access restrictions, define user roles, and ensure secure tracking of analysis and instrument events, ensuring compliance with regulatory standards.
