NEXT-GENERATION BIOCALORIMETRY SYSTEMS
Expanding on the proven calScreener® platform, the caloTrace® detection system utilizes highly sensitive isothermal microcalorimetry technology, detecting the heat released by living cells and microorganisms with exceptional sensitivity.
There is no need for reagents, enrichment, filtration, lysis, or other disruptive sample preparation steps. Even complex sample types, including creams, powders, food samples, liquids, and solid materials, can be tested directly in sample volumes of up to 10 mL.
Operating at controlled temperatures from 20 to 40°C, the system accommodates a broad range of applications, from microbial and cellular metabolism studies to formulation, stability, and reaction monitoring. Configure the caloTrace to match your needs, either as a complete workstation solution or as a standalone instrument.
RAPID, AUTOMATED AND SIMPLIFIED MICROBIAL MEASUREMENTS
The caloTrace sets a new standard for microbial testing, introducing a number of new benefits. High-sensitivity detection of bacteria, yeast, and mold combined with rapid and continuous monitoring enables operators to take immediate action as soon as microbial presence is detected.
Samples, including complex and difficult matrices, can be analyzed directly in test vials with standard media without filtration, reagents, or cumbersome and error-prone handling steps. The system enables testing of up to 30 samples in parallel, with each position loaded independently for maximum flexibility and throughput. Clear automated pass/fail results remove subjective interpretation errors, while detection of only viable microorganisms minimizes the risk of false results.
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Continuous monitoring with time to detection in hours
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Detection of only viable microorganisms with minimal risk of false results
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Simplified workflows with no filtration or reagents required
FASTER MICROBIAL TESTING, FASTER RESPONSE TO CONTAMINATIONS
The sooner issues are identified, the sooner corrective actions can be taken. Traditional and alternative microbial testing methods often require several days to deliver results and only provide end-point measurements. The caloTrace® can detect many microorganisms in a few hours, and its continuous real-time monitoring means there is no need to wait for the full test cycle to finish — contamination is automatically flagged as soon as it is detected.
From personal care and over-the-counter (OTC) products to food and beverages, ingredients, biomaterials, and industrial formulations , the caloTrace simplifies workflows and accelerates timelines, enabling faster product release with greater confidence in microbial test results.
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Reduce inventory and improve warehouse utilization
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Shorten production and release cycles
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Respond faster to contamination events
METABOLIC ANALYSIS OF COMPLEX BIOLOGICAL SYSTEMS
Based on isothermal microcalorimetry, the system expands the flexibility of biocalorimetry and metabolic monitoring for testing and research of organic materials. Sample volumes of up to 10 mL can be analyzed across a wide range of applications, including mammalian cells, tissue biopsies, yeasts, fungi, algae, plants, grains, and soil samples.
Conventional techniques frequently require extensive sample preparation, optical clarity, or sample disruption, which slows workflows and increases the risk of non-representative results. Since heat production is an intrinsic property of life, biocalorimetry enables direct, in situ, continuous, and non-destructive biological detection without altering the sample.
STREAMLINED WORKFLOW
The caloTrace combines sensitive measurement with practical sample handling. Using autoclavable crimp-cap glass vials, the system accommodates both liquid and solid samples prepared by weighing, pipetting, or direct injection. Add 10 mL sample or sample-media mix to a 13 mL vial – if less than 10 mL, fill up with media – cap vial. Once sealed, samples are monitored non-destructively in real time, preserving material integrity and allowing retrieval for follow-up characterization or further analytical testing.
The simplicity of the workflow not only makes testing easier for operators, but also improves reliability and reproducibility. The simpler an analytical method is, the lower the risk of operator errors and the more reliable the results become.
Independent Channels, reliable Data
Featuring 30 independent isothermal calorimetric channels equipped with high-performance heat flow detectors, the caloTrace is designed for stable and reliable operation. Each detection unit contains a built-in reference and no integrated moving parts, ensuring long-term reliability while minimizing the risk of downtime.
The sensors in each channel are extremely sensitive, capable of capturing even very small amounts of metabolic heat released by microorganisms, enabling single-CFU limits of detection. Unlike systems that rely on multiple secondary optical measurements, the caloTrace provides a more direct and rapid microbial detection method unaffected by sample viscosity or variability in optical clarity.
CALVIAL - PRECISION SAMPLING
Measurements are performed using autoclavable caloTrace 13 mL calVials™ with a total sample volume of up to 10 mL. Samples can either be added through the septum or filled directly into the vial prior to sealing with a crimping tool using autoclavable crimp-cap glass vials.
calView
The calView® software interface streamlines the entire workflow—from sample entry to result reporting. It allows real-time monitoring of all measurements and offers flexible data visualization, from full experiment overviews and data exports to individual sample curves. It transforms complex thermal data into intuitive, interpretable results for confident decision-making.
For QC microbial testing applications it can se set up to provide automatic positive/negative results and analysis reports. The system supports 21 CFR Part 11 data integrity requirements with audit logs, user roles, and secure electronic documentation.
SYMCEL SERVICE & SUPPORT
When selecting a Symcel system, your success is our priority. Our team of scientists and engineers provides comprehensive support to ensure your methods are optimized and your system delivers maximum value.
From initial feasibility studies and method development to installation, validation, service and training, we support you at every step.
Testing and studies are supported by our qualified laboratory on the Karolinska Institute premises in Stockholm, with broad capabilities in eukaryotic and microbiological testing, together with partner laboratories and analytical service providers.
